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What are aquaporin-4 antibodies?

The antibodies for aquaporin-4 are a highly sensitive and highly specific marker in serum for neuromyelitis Optica (NMO) which can aid in the identification of NMO and classical MS. You can know more about aquaporin-4 antibodies via

Aquaporin 4 Antibody (PA5-85767)

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NMO-IgG/AQP4Ab seropositive status also has significant prognostic and therapeutic significance for patients with isolated long-term extensive myelitis (LETM) or optic neuritis (ON). The article we present here will thoroughly examine and critically evaluate the current literature on NMO IgG/AQP4 Ab testing. 

Estimates of sensitivity, specificity as well as the likelihood of a positive or negative ratio are determined for each research study and the accuracy of the different methods of immunoassay can be compared. 

Subgroup analyses are offered on NMO, LETM, and ON for relapsing vs. monophasic diseases, as well as for different groupings of controls (eg, MS vs. other controls). 

A variety of aspects of NMO-IgG/AQP4-Ab testing are important for physicians (eg the effect of antibody titers as well as longitudinal tests, the need for repeat testing the importance of CSF testing, and subclass analysis NMO-IgG/AQP4-Ab testing in patients suffering from r illnesses) and also technical aspects (eg the AQP4-M1 assay in comparison to. 

An AQP4-M23 assay in the absence of AQP4 as compared to. the peptide substrates, and the effect on storage conditions and freezing and thawing cycles) and the potential pitfalls are addressed.